Turning innovation into scalable solutions
Innovative ideas deserve efficient and reliable pathways to manufacturing. The right combination of expertise, technology, and integrated services helps transform breakthrough concepts into technically and commercially viable products.
Tailored services
Our comprehensive service portfolio supports every stage from development and scale-up to industrial production, helping teams overcome technical challenges, improve efficiency, and reduce manufacturing costs.
Fast, efficient, and cost-effective solutions are provided across molecular biology, protein expression, plasmid DNA production, and purification. These services support innovators in bringing high-quality products to market with confidence.
Benefits
Take advantage of our E. coli-based technology platform for your project. Built and expanded for over a decade, our platform has consistently enabled the efficient production of complex and challenging molecules, unlocking possibilities that conventional platforms struggle to achieve.
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By decoupling cell growth and recombinant production, metabolic resources are directed towards product formation. This results in highter product titers, improved protein solubility, and access to difficult-to-express proteins.
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The opportunity of extracellular production significantly simplifies downstream processing and reduces overall manufacturing costs.
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The option for end-to-end continuous bioprocessing unlocks small-footpring manufacturing and cuts CAPEX.
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Antibiotic-resistance marker free production improvides regulatory compliance.
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... and much more to explore.
Industries served
enGenes Biotech is the trusted partner for innovative companies of all sizes, from startups to medium and large enterprises, across a wide range of industries. Our expertise supports businesses in pharmaceuticals, diagnostics, food and feed, cosmetics, personal care, and flavors & fragrances, as well as many other specialised markets.
Products supported
Benefit from E. coli-based processes capable of handling a wide range of molecules. This includes recombinant proteins such as peptides, enzymes, therapeutic proteins, and antibody fragments, as well as supercoiled plasmid DNA for gene therapy, vaccines, and synthetic biology applications. The platform also supports the incorporation of non-canonical amino acids, enabling click chemistry, bioconjugation, and immobilisation, and helping teams develop novel, functionalized biomolecules for research, diagnostics, and industrial applications.
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In the first phase, multiple host and vector combinations are generated and screened using high-throughput microbioreactor systems to identify optimal expression conditions. For recombinant proteins, the focus is on achieving high levels of soluble protein, with the option to evaluate extracellular secretion. The resulting data provide early insights into expected performance in larger-scale fed-batch processes.
4-6 weeks
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In the second phase, selected candidates are validated in fed-batch mode using a 4 × 1 L multibioreactor system. This enables parallel comparison of strains and process conditions under well-controlled environments, supporting preliminary manufacturability assessment. The study delivers a comprehensive data set highlighting scalability, robustness, and performance trends relevant to industrial fermentation.
4-6 weeks
Technology transfer
Benefit from agile and flexible process development that enables rapid and cost-effective optimisation and efficient production of batches for early-stage needs. As projects progress and demand grows, production processes can be seamlessly transferred to large-scale partners and cGMP facilities. Our strong connections within the CDMO ecosystem ensure a smooth transition, supporting reliable scale-up and continued success.
Strain development
Genetic engineering and vector design combined with high-throughput screening to rapidly assess and identify lead candidates for recombinant production in E. coli.
Upstream development
Development of fed-batch and continuous processes, from microliter-scale optimisation to scale up and process validation at up to 200L.
Downstream development
Establishment of primary and secondary downstream unit operations with your targeted purity grade and production costs in mind.
Contract manufacturing
Flexible contract manufacturing supporting diverse volume needs, agile lead times, and delivery of purified, research-grade materials.
Analytical support
Including method transfer and analytical method development to ensure accurate assessment of your product's critical quality attributes.
