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New White Paper: Precision Meets Multiplexing in Tissue Diagnostics

  • Writer: Juergen Mairhofer
    Juergen Mairhofer
  • Jul 17
  • 1 min read

We're excited to share a new collaborative white paper from enGenes Biotech and arcoris bio, tackling one of the biggest bottlenecks in multiplex immunofluorescence: inconsistent, hard-to-scale antibody labeling.


Traditional conjugation chemistries produce heterogeneous reagents that limit reproducibility — a real problem as multiplex panels grow more complex.


Our combined approach pairs two complementary technologies:


enGenes' eXpand — site-specific incorporation of non-canonical amino acids (ncAAs) via amber codon suppression, creating "ready-to-click" proteins with defined labeling sites and stoichiometry, at yields approaching wild-type E. coliproduction.


arcoris bio's MUSE® — a modular, multiplex signal amplification platform. The site-specific MUSE® Activatorcreates a standardized interface on eXpand-produced proteins for downstream detection chemistry.


Using TNF-α and HER2 as model biomarkers, we demonstrate specific, high-contrast detection in FFPE tissue — showing how genetically encoded precision + modular tagging can deliver the reproducibility, flexibility, and scalability that quantitative multiplex IHC demands.


Read the full white paper here to see the data and workflow in detail.


Interested in custom construct development, licensing, or a collaborative R&D partnership? We'd love to hear from you.




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